Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles

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Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles

In many secretory cells actin and myosin are specifically recruited to the surface of secretory granules following their fusion with the plasma membrane. Actomyosin-dependent compression of fused granules is essential to promote active extrusion of cargo. However, little is known about molecular mechanisms regulating actin coat formation and contraction. Here, we provide a detailed kinetic anal...

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Secretion of vesicular contents by exocytosis is a fundamental cellular process. Increasing evidence suggests that post-fusion events play an important role in determining the composition and quantity of the secretory output. In particular, regulation of fusion pore dilation and closure is considered a key regulator of the post-fusion phase. However, depending on the nature of the cargo, additi...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2015

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.165571